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Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR–Cas12f nuclease
Cas12f, also known as Cas14, is an exceptionally small type V-F CRISPR–Cas nuclease that is roughly half the size of comparable nucleases of this type. To reveal the mechanisms underlying substrate recognition and cleavage, we determined the cryo-EM structures of the Cas12f-sgRNA-target DNA and Cas1...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8053092/ https://ncbi.nlm.nih.gov/pubmed/33764415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab179 |
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