Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers

Resveratrol (RVT) derivatives (10a-i) were designed, synthesized, and evaluated for their potential as gamma-globin inducers in treating Sickle Cell Disease (SCD) symptoms. All compounds were able to release NO at different levels ranging from 0–26.3%, while RVT did not demonstrate this effect. In v...

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Publicat a:Bioorg Chem
Autors principals: Bosquesi, Priscila Longhin, Melchior, Aylime Castanho Bolognesi, Pavan, Aline Renata, Lanaro, Carolina, de Souza, Cristiane Maria, Rusinova, Radda, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, Fernandes, Guilherme Felipe dos Santos, Carlos, Iracilda Zepone, Andersen, Olaf Sparre, Costa, Fernando Ferreira, Dos Santos, Jean Leandro
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052979/
https://ncbi.nlm.nih.gov/pubmed/32450391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.103948
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