Antiplatelet and Antithrombotic Activities of Non-Steroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

Nonsteroidal anti-inflammatory drugs (NSAIDs) 1–5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities assessed in vitro and in vivo. Compounds 1–5 inhibited the platelet aggregation induced by adenosine diphosphate and/or arachidonic acid, with i...

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Published in:Molecules
Main Authors: Chelucci, Rafael Consolin, Dutra, Luiz Antônio, Pires, Maria Elisa Lopes, de Melo, Thais Regina Ferreira, Bosquesi, Priscila Longhin, Chung, Man Chin, dos Santos, Jean Leandro
Format: Artigo
Language:Inglês
Published: MDPI 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270978/
https://ncbi.nlm.nih.gov/pubmed/24549233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19022089
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