Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display sim...

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Hlavní autoři: de Melo, Thais Regina Ferreira, Chelucci, Rafael Consolin, Pires, Maria Elisa Lopes, Dutra, Luiz Antonio, Barbieri, Karina Pereira, Bosquesi, Priscila Longhin, Trossini, Gustavo Henrique Goulart, Chung, Man Chin, dos Santos, Jean Leandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Diversity Preservation International (MDPI) 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013598/
https://ncbi.nlm.nih.gov/pubmed/24714090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15045821
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