Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display sim...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: de Melo, Thais Regina Ferreira, Chelucci, Rafael Consolin, Pires, Maria Elisa Lopes, Dutra, Luiz Antonio, Barbieri, Karina Pereira, Bosquesi, Priscila Longhin, Trossini, Gustavo Henrique Goulart, Chung, Man Chin, dos Santos, Jean Leandro
פורמט: Artigo
שפה:Inglês
יצא לאור: Molecular Diversity Preservation International (MDPI) 2014
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013598/
https://ncbi.nlm.nih.gov/pubmed/24714090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15045821
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