Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display sim...

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Main Authors: de Melo, Thais Regina Ferreira, Chelucci, Rafael Consolin, Pires, Maria Elisa Lopes, Dutra, Luiz Antonio, Barbieri, Karina Pereira, Bosquesi, Priscila Longhin, Trossini, Gustavo Henrique Goulart, Chung, Man Chin, dos Santos, Jean Leandro
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Diversity Preservation International (MDPI) 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013598/
https://ncbi.nlm.nih.gov/pubmed/24714090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15045821
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