Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display sim...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: de Melo, Thais Regina Ferreira, Chelucci, Rafael Consolin, Pires, Maria Elisa Lopes, Dutra, Luiz Antonio, Barbieri, Karina Pereira, Bosquesi, Priscila Longhin, Trossini, Gustavo Henrique Goulart, Chung, Man Chin, dos Santos, Jean Leandro
Format: Artigo
Langue:Inglês
Publié: Molecular Diversity Preservation International (MDPI) 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013598/
https://ncbi.nlm.nih.gov/pubmed/24714090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15045821
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires