Synthesis, Structure-Activity Relationships and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease

Flaviviruses, including Zika, dengue and West Nile virus, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication and therefore a promising drug target. Through compound screen followed by medicinal chemistry studies, a novel series of 2...

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Publicado no:J Med Chem
Main Authors: Nie, Shenyou, Yao, Yuan, Wu, Fangrui, Wu, Xiaowei, Zhao, Jidong, Hua, Yuanda, Wu, Jingyu, Huo, Tong, Lin, Yi-Lun, Kneubehl, Alexander R., Vogt, Megan B., Ferreon, Josephine, Rico-Hesse, Rebecca, Song, Yongcheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052950/
https://ncbi.nlm.nih.gov/pubmed/33596380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02070
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