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Role of Gly197 in the structure and function of protein C

We previously demonstrated that heterozygous Gly197 to Arg mutation in PROC is associated with venous thrombosis due to the mutation abrogating both zymogenic and enzymatic activities of protein C and activated protein C (APC). In this study, we investigated the role of Gly197 on the structure and f...

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Détails bibliographiques
Publié dans:Biochim Biophys Acta Gen Subj
Auteurs principaux: Lu, Yeling, Biswas, Indranil, Villoutreix, Bruno O., Rezaie, Alireza R.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052293/
https://ncbi.nlm.nih.gov/pubmed/33722640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2021.129892
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