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Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators of transcription....
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| Veröffentlicht in: | Cell Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cell Press
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052185/ https://ncbi.nlm.nih.gov/pubmed/33852840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108977 |
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