Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm(−/−) mouse models are particularly pred...

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Udgivet i:Nat Commun
Main Authors: Álvarez-Quilón, Alejandro, Terrón-Bautista, José, Delgado-Sainz, Irene, Serrano-Benítez, Almudena, Romero-Granados, Rocío, Martínez-García, Pedro Manuel, Jimeno-González, Silvia, Bernal-Lozano, Cristina, Quintero, Cristina, García-Quintanilla, Lourdes, Cortés-Ledesma, Felipe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021672/
https://ncbi.nlm.nih.gov/pubmed/32060399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14638-w
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