Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility

DNA topoisomerase II-β (TOP2B) is fundamental to remove topological problems linked to DNA metabolism and 3D chromatin architecture, but its cut-and-reseal catalytic mechanism can accidentally cause DNA double-strand breaks (DSBs) that can seriously compromise genome integrity. Understanding the fac...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Martínez-García, Pedro Manuel, García-Torres, Miguel, Divina, Federico, Terrón-Bautista, José, Delgado-Sainz, Irene, Gómez-Vela, Francisco, Cortés-Ledesma, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845959/
https://ncbi.nlm.nih.gov/pubmed/33465072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007814
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