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Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators of transcription....
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| 發表在: | Cell Rep |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cell Press
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052185/ https://ncbi.nlm.nih.gov/pubmed/33852840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108977 |
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