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Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells

Sound detection happens in the inner ear via the mechanical deflection of the hair bundle of cochlear hair cells. The hair bundle is an apical specialization consisting of actin-filled membrane protrusions (called stereocilia) connected by tip links (TLs) that transfer the deflection force to gate t...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Trouillet, Alix, Miller, Katharine K., George, Shefin Sam, Wang, Pei, Ali, Noor-E-Seher, Ricci, Anthony, Grillet, Nicolas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051682/
https://ncbi.nlm.nih.gov/pubmed/33707295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0975-20.2021
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