Harmonin mutations cause mechanotransduction defects in cochlear hair cells

In hair cells, mechanotransduction channels are gated by tip links, the extracellular filaments that consist of cadherin 23 (CDH23) and protocadherin 15 (PCDH15) and connect the stereocilia of each hair cell. However, which molecules mediate cadherin function at tip links is not known. Here we show...

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Hauptverfasser: Grillet, Nicolas, Xiong, Wei, Reynolds, Anna, Kazmierczak, Piotr, Sato, Takashi, Lillo, Concepcion, Dumont, Rachel A., Hintermann, Edith, Sczaniecka, Anna, Schwander, Martin, Williams, David, Kachar, Bechara, Gillespie, Peter G., Müller, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691393/
https://ncbi.nlm.nih.gov/pubmed/19447093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.04.006
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