Harmonin mutations cause mechanotransduction defects in cochlear hair cells

In hair cells, mechanotransduction channels are gated by tip links, the extracellular filaments that consist of cadherin 23 (CDH23) and protocadherin 15 (PCDH15) and connect the stereocilia of each hair cell. However, which molecules mediate cadherin function at tip links is not known. Here we show...

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Main Authors: Grillet, Nicolas, Xiong, Wei, Reynolds, Anna, Kazmierczak, Piotr, Sato, Takashi, Lillo, Concepcion, Dumont, Rachel A., Hintermann, Edith, Sczaniecka, Anna, Schwander, Martin, Williams, David, Kachar, Bechara, Gillespie, Peter G., Müller, Ulrich
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691393/
https://ncbi.nlm.nih.gov/pubmed/19447093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.04.006
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