Harmonin mutations cause mechanotransduction defects in cochlear hair cells

In hair cells, mechanotransduction channels are gated by tip links, the extracellular filaments that consist of cadherin 23 (CDH23) and protocadherin 15 (PCDH15) and connect the stereocilia of each hair cell. However, which molecules mediate cadherin function at tip links is not known. Here we show...

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Auteurs principaux: Grillet, Nicolas, Xiong, Wei, Reynolds, Anna, Kazmierczak, Piotr, Sato, Takashi, Lillo, Concepcion, Dumont, Rachel A., Hintermann, Edith, Sczaniecka, Anna, Schwander, Martin, Williams, David, Kachar, Bechara, Gillespie, Peter G., Müller, Ulrich
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691393/
https://ncbi.nlm.nih.gov/pubmed/19447093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.04.006
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