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Structure of 3′-PO(4)/5′-OH RNA ligase RtcB in complex with a 5′-OH oligonucleotide
RtcB enzymes comprise a widely distributed family of manganese- and GTP-dependent RNA repair enzymes that join 2′,3′-cyclic phosphate ends to 5′-OH ends via RtcB-(histidinyl-N)–GMP, RNA 3′-phosphate, and RNA(3′)pp(5′)G intermediates. RtcB can ligate either 5′-OH RNA or 5′-OH DNA strands in vitro. Th...
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| Publicado no: | RNA |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8051266/ https://ncbi.nlm.nih.gov/pubmed/33619169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.078692.121 |
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