Structure and two-metal mechanism of fungal tRNA ligase

Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodiesterase (CPD) and central GTP-depend...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Banerjee, Ankan, Ghosh, Shreya, Goldgur, Yehuda, Shuman, Stewart
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379707/
https://ncbi.nlm.nih.gov/pubmed/30590734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1275
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