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Structure of 3′-PO(4)/5′-OH RNA ligase RtcB in complex with a 5′-OH oligonucleotide

RtcB enzymes comprise a widely distributed family of manganese- and GTP-dependent RNA repair enzymes that join 2′,3′-cyclic phosphate ends to 5′-OH ends via RtcB-(histidinyl-N)–GMP, RNA 3′-phosphate, and RNA(3′)pp(5′)G intermediates. RtcB can ligate either 5′-OH RNA or 5′-OH DNA strands in vitro. Th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RNA
Prif Awduron: Banerjee, Ankan, Goldgur, Yehuda, Shuman, Stewart
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051266/
https://ncbi.nlm.nih.gov/pubmed/33619169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.078692.121
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