Protocol for rapid assessment of the efficacy of novel Wnt inhibitors using zebrafish models

Dysregulation of Wnt signaling is a hallmark of many cancers, and the development of effective, non-toxic small-molecule Wnt inhibitors is desirable. Off-target toxicities of new compounds are typically tested in mouse models, which is both costly and time consuming. Here, we present a rapid and ine...

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Vydáno v:STAR Protoc
Hlavní autoři: Haney, Meghan G., Wimsett, Mary, Liu, Chunming, Blackburn, Jessica S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Protocol
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050796/
https://ncbi.nlm.nih.gov/pubmed/33889852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2021.100433
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