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Zebrafish as a model to assess cancer heterogeneity, progression and relapse

Clonal evolution is the process by which genetic and epigenetic diversity is created within malignant tumor cells. This process culminates in a heterogeneous tumor, consisting of multiple subpopulations of cancer cells that often do not contain the same underlying mutations. Continuous selective pre...

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Autori principali: Blackburn, Jessica S., Langenau, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Limited 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073265/
https://ncbi.nlm.nih.gov/pubmed/24973745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.015842
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