Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg(2+) reabsorption. Here, we used a Cnnm2 knock out mouse model, generated by CRIS...

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Pubblicato in:Sci Rep
Autori principali: Franken, Gijs A. C., Seker, Murat, Bos, Caro, Siemons, Laura A. H., van der Eerden, Bram C. J., Christ, Annabel, Hoenderop, Joost G. J., Bindels, René J. M., Müller, Dominik, Breiderhoff, Tilman, de Baaij, Jeroen H. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050252/
https://ncbi.nlm.nih.gov/pubmed/33859252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87548-6
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