Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg(2+) reabsorption. Here, we used a Cnnm2 knock out mouse model, generated by CRIS...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Franken, Gijs A. C., Seker, Murat, Bos, Caro, Siemons, Laura A. H., van der Eerden, Bram C. J., Christ, Annabel, Hoenderop, Joost G. J., Bindels, René J. M., Müller, Dominik, Breiderhoff, Tilman, de Baaij, Jeroen H. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050252/
https://ncbi.nlm.nih.gov/pubmed/33859252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87548-6
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