The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more subtle polymorphic variations influencing the pop...

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Publicado en:Mol Metab
Main Authors: Yeo, Giles S.H., Chao, Daniela Herrera Moro, Siegert, Anna-Maria, Koerperich, Zoe M., Ericson, Mark D., Simonds, Stephanie E., Larson, Courtney M., Luquet, Serge, Clarke, Iain, Sharma, Shubh, Clément, Karine, Cowley, Michael A., Haskell-Luevano, Carrie, Van Der Ploeg, Lex, Adan, Roger A.H.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050006/
https://ncbi.nlm.nih.gov/pubmed/33684608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101206
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