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MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca(2+) Leak
RATIONALE: In heart failure (HF), impaired sarcoplasmic reticulum (SR) Ca(2+) release and cytosolic Na(+) overload depress mitochondrial Ca(2+) (mCa(2+)) signaling, resulting in a diminished ability to maintain matrix NAD(P)H redox potential, leading to increased oxidative stress when workload incre...
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| Published in: | Circ Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8049980/ https://ncbi.nlm.nih.gov/pubmed/33522833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.318562 |
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