Inhibiting Mitochondrial Na(+)/Ca(2+) Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

RATIONALE: In cardiomyocytes from failing hearts, insufficient mitochondrial Ca(2+) ([Ca(2+)](m)) accumulation secondary to cytoplasmic Na(+) overload decreases NAD(P)H/NAD(P)(+) redox potential and increases oxidative stress when workload increases. These effects are abolished by enhancing [Ca(2+)]...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: Liu, Ting, Takimoto, Eiki, Dimaano, Veronica L., DeMazumder, Deeptankar, Kettlewell, Sarah, Smith, Godfrey, Sidor, Agnieszka, Abraham, Theodore P., O’Rourke, Brian
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219273/
https://ncbi.nlm.nih.gov/pubmed/24780171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303062
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki