Inhibiting Mitochondrial Na(+)/Ca(2+) Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

RATIONALE: In cardiomyocytes from failing hearts, insufficient mitochondrial Ca(2+) ([Ca(2+)](m)) accumulation secondary to cytoplasmic Na(+) overload decreases NAD(P)H/NAD(P)(+) redox potential and increases oxidative stress when workload increases. These effects are abolished by enhancing [Ca(2+)]...

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Publicado no:Circ Res
Main Authors: Liu, Ting, Takimoto, Eiki, Dimaano, Veronica L., DeMazumder, Deeptankar, Kettlewell, Sarah, Smith, Godfrey, Sidor, Agnieszka, Abraham, Theodore P., O’Rourke, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219273/
https://ncbi.nlm.nih.gov/pubmed/24780171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303062
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