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The Ca(2+) leak paradox and “rogue ryanodine receptors”: SR Ca(2+) efflux theory and practice

Ca(2+) efflux from the sarcoplasmic reticulum (SR) is routed primarily through SR Ca(2+) release channels (ryanodine receptors, RyRs). When clusters of RyRs are activated by trigger Ca(2+) influx through L-type Ca(2+) channels (dihydropyridine receptors, DHPR), Ca(2+) sparks are observed. Close spat...

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書誌詳細
主要な著者: Sobie, Eric A., Guatimosim, Silvia, Gómez-Viquez, Leticia, Song, Long-Sheng, Hartmann, Hali, Jafri, M. Saleet, Lederer, W.J.
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484520/
https://ncbi.nlm.nih.gov/pubmed/16326215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2005.06.010
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