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CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes

OBJECTIVE: Doxorubicin (DOX) is one of the most effective chemotherapeutic agents, but cardiotoxicity limits DOX therapy. Although the mechanisms are not entirely understood, reactive oxygen species (ROS) appear to be involved in DOX cardiotoxicity. Ca/calmodulin dependent protein kinase II (CaMKII)...

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Detalhes bibliográficos
Main Authors: Sag, Can M., Köhler, Anne C., Anderson, Mark E., Backs, Johannes, Maier, Lars S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226826/
https://ncbi.nlm.nih.gov/pubmed/21819992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.07.016
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