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Late I(Na) increases diastolic SR-Ca(2+)-leak in atrial myocardium by activating PKA and CaMKII
AIMS: Enhanced cardiac late Na current (late I(Na)) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late I(Na) and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs). METHODS AND RESULTS: In murine atri...
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| Publicado no: | Cardiovasc Res |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476413/ https://ncbi.nlm.nih.gov/pubmed/25990311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv153 |
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