Late I(Na) increases diastolic SR-Ca(2+)-leak in atrial myocardium by activating PKA and CaMKII

AIMS: Enhanced cardiac late Na current (late I(Na)) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late I(Na) and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs). METHODS AND RESULTS: In murine atri...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cardiovasc Res
Glavni autori: Fischer, Thomas H., Herting, Jonas, Mason, Fleur E., Hartmann, Nico, Watanabe, Saera, Nikolaev, Viacheslav O., Sprenger, Julia U., Fan, Peidong, Yao, Lina, Popov, Aron-Frederik, Danner, Bernhard C., Schöndube, Friedrich, Belardinelli, Luiz, Hasenfuss, Gerd, Maier, Lars S., Sossalla, Samuel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476413/
https://ncbi.nlm.nih.gov/pubmed/25990311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv153
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items