Late I(Na) increases diastolic SR-Ca(2+)-leak in atrial myocardium by activating PKA and CaMKII

AIMS: Enhanced cardiac late Na current (late I(Na)) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late I(Na) and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs). METHODS AND RESULTS: In murine atri...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Fischer, Thomas H., Herting, Jonas, Mason, Fleur E., Hartmann, Nico, Watanabe, Saera, Nikolaev, Viacheslav O., Sprenger, Julia U., Fan, Peidong, Yao, Lina, Popov, Aron-Frederik, Danner, Bernhard C., Schöndube, Friedrich, Belardinelli, Luiz, Hasenfuss, Gerd, Maier, Lars S., Sossalla, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476413/
https://ncbi.nlm.nih.gov/pubmed/25990311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv153
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