Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII

Ionizing radiation (IR) is an integral part of modern multimodal anti-cancer therapies. IR involves the formation of reactive oxygen species (ROS) in targeted tissues. This is associated with subsequent cardiac dysfunction when applied during chest radiotherapy. We hypothesized that IR (i.e., ROS)-d...

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Detalhes bibliográficos
Main Authors: Sag, Can M., Wolff, Hendrik A., Neumann, Kay, Opiela, Marie-Kristin, Zhang, Juqian, Steuer, Felicia, Sowa, Thomas, Gupta, Shamindra, Schirmer, Markus, Hünlich, Mark, Rave-Fränk, Margret, Hess, Clemens F., Anderson, Mark E., Shah, Ajay M., Christiansen, Hans, Maier, Lars S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898380/
https://ncbi.nlm.nih.gov/pubmed/24068185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-013-0385-6
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