Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric genetic studies and limited knowledge of shared causal variants. Leveraging regulatory annotations may improve portability by prioritizing functional over tagging variants. We constructed a resource of 707 cell-...

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Gepubliceerd in:Nat Genet
Hoofdauteurs: Amariuta, Tiffany, Ishigaki, Kazuyoshi, Sugishita, Hiroki, Ohta, Tazro, Koido, Masaru, Dey, Kushal K., Matsuda, Koichi, Murakami, Yoshinori, Price, Alkes L., Kawakami, Eiryo, Terao, Chikashi, Raychaudhuri, Soumya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049522/
https://ncbi.nlm.nih.gov/pubmed/33257898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00740-8
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