GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380 Japanese men, we identify 50 independent genetic markers in 46 loci associated with m...

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保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Terao, Chikashi, Momozawa, Yukihide, Ishigaki, Kazuyoshi, Kawakami, Eiryo, Akiyama, Masato, Loh, Po-Ru, Genovese, Giulio, Sugishita, Hiroki, Ohta, Tazro, Hirata, Makoto, Perry, John R. B., Matsuda, Koichi, Murakami, Yoshinori, Kubo, Michiaki, Kamatani, Yoichiro
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797717/
https://ncbi.nlm.nih.gov/pubmed/31624269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12705-5
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