Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population

The functional variants involved in alcohol metabolism, the A allele of rs1229984:A > G in ADH1B and the A allele of rs671:G > A in ALDH2, are specifically prevalent among East Asian population. They are shown to be under recent positive selection, but the reasons for the selection are unknown...

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Vydáno v:Eur J Hum Genet
Hlavní autoři: Sakaue, Saori, Akiyama, Masato, Hirata, Makoto, Matsuda, Koichi, Murakami, Yoshinori, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2019
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028931/
https://ncbi.nlm.nih.gov/pubmed/31558841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-019-0518-y
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