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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations may be partl...

詳細記述

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書誌詳細
出版年:Genet Epidemiol
主要な著者: Chen, Chia-Yen, Han, Jiali, Hunter, David J., Kraft, Peter, Price, Alkes L.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734143/
https://ncbi.nlm.nih.gov/pubmed/25995153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21906
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