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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction
Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations may be partl...
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| Publié dans: | Genet Epidemiol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4734143/ https://ncbi.nlm.nih.gov/pubmed/25995153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21906 |
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