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Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide

Post-translational modifications are often detected in age-related diseases associated with protein misfolding such as cataracts from aged lenses. One of the major post-translational modifications is the isomerization of aspartate residues (L-isoAsp), which could be non-enzymatically and spontaneous...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Magami, Kosuke, Hachiya, Naomi, Morikawa, Kazuo, Fujii, Noriko, Takata, Takumi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049310/
https://ncbi.nlm.nih.gov/pubmed/33857260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250277
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