Nalaganje...

Isomeric Replacement of a Single Aspartic Acid Induces a Marked Change in Protein Function: The Example of Ribonuclease A

[Image: see text] lα-Aspartic acid (Asp) residues in proteins are nonenzymatically isomerized to abnormal lβ-, dα-, and dβ-Asp isomers under physiological conditions. Such an isomerization of Asp residues is considered to be a trigger of protein denaturation because it either elongates the main chai...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Omega
Main Authors: Sakaue, Hiroaki, Kinouchi, Tadatoshi, Fujii, Norihiko, Takata, Takumi, Fujii, Noriko
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6641078/
https://ncbi.nlm.nih.gov/pubmed/31457226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00346
Oznake: Označite
Brez oznak, prvi označite!