Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation

Tubulysins have emerged in recent years as a compelling drug class for delivery to tumor cells via antibodies. The ability of this drug class to exert bystander activity while retaining potency against multidrug‐resistant cell lines differentiates them from other microtubule‐disrupting agents. Tubul...

詳細記述

保存先:
書誌詳細
出版年:ChemMedChem
主要な著者: Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2021
主題:
Communications
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048973/
https://ncbi.nlm.nih.gov/pubmed/33369163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000889
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