Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation

Tubulysins have emerged in recent years as a compelling drug class for delivery to tumor cells via antibodies. The ability of this drug class to exert bystander activity while retaining potency against multidrug‐resistant cell lines differentiates them from other microtubule‐disrupting agents. Tubul...

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Bibliografische gegevens
Gepubliceerd in:ChemMedChem
Hoofdauteurs: Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
Onderwerpen:
Communications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048973/
https://ncbi.nlm.nih.gov/pubmed/33369163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000889
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