CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering

CYP154C5 from Nocardia farcinica is a P450 monooxygenase able to hydroxylate a range of steroids with high regio‐ and stereoselectivity at the 16α‐position. Using protein engineering and substrate modifications based on the crystal structure of CYP154C5, an altered regioselectivity of the enzyme in...

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Bibliografiske detaljer
Udgivet i:Chembiochem
Main Authors: Bracco, Paula, Wijma, Hein J., Nicolai, Bastian, Buitrago, Jhon Alexander Rodriguez, Klünemann, Thomas, Vila, Agustina, Schrepfer, Patrick, Blankenfeldt, Wulf, Janssen, Dick B., Schallmey, Anett
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048783/
https://ncbi.nlm.nih.gov/pubmed/33145893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000735
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