CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering

CYP154C5 from Nocardia farcinica is a P450 monooxygenase able to hydroxylate a range of steroids with high regio‐ and stereoselectivity at the 16α‐position. Using protein engineering and substrate modifications based on the crystal structure of CYP154C5, an altered regioselectivity of the enzyme in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Bracco, Paula, Wijma, Hein J., Nicolai, Bastian, Buitrago, Jhon Alexander Rodriguez, Klünemann, Thomas, Vila, Agustina, Schrepfer, Patrick, Blankenfeldt, Wulf, Janssen, Dick B., Schallmey, Anett
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048783/
https://ncbi.nlm.nih.gov/pubmed/33145893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000735
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados