Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

Small-cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic screens, we identified inhibition of ataxia telangiectasia and Rad3-related (ATR), primary activator of the replication stress response, and to...

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Publicado no:Cancer Cell
Main Authors: Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N., Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M., Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W., Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E., Kindrick, Jessica D., Peer, Cody J., Wei, Jun S., Aladjem, Mirit I., Figg, William Douglas, Steinberg, Seth M., Trepel, Jane B., Zenke, Frank T., Pommier, Yves, Khan, Javed, Thomas, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048383/
https://ncbi.nlm.nih.gov/pubmed/33848478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2021.02.014
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