Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Huntington’s disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in the cell bodies of neurons in brain sections from presymptom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol Commun
Prif Awduron: Zhou, Ya, Peskett, Thomas R., Landles, Christian, Warner, John B., Sathasivam, Kirupa, Smith, Edward J., Chen, Shu, Wetzel, Ronald, Lashuel, Hilal A., Bates, Gillian P., Saibil, Helen R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2021
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048291/
https://ncbi.nlm.nih.gov/pubmed/33853668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01172-z
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