SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis

Serine palmitoyltransferase complex (SPT) mediates the first and rate-limiting step in the de novo sphingolipid biosynthetic pathway. The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a smaller third subunit either SSSPTA or SSSPTB has been shown to increase the cat...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Parthibane, Velayoudame, Lin, Jing, Acharya, Diwash, Abimannan, Thiruvaimozhi, Srideshikan, Sargur Madabushi, Klarmann, Kimberly, Yang, Acong, Soheilian, Ferri, Nagashima, Kunio, Fox, Stephen D., Andresson, Thorkell, Tessarollo, Lino, Keller, Jonathan R., Acharya, Usha, Acharya, Jairaj K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047174/
https://ncbi.nlm.nih.gov/pubmed/33662400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100491
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