The folate cycle enzyme MTHFR is a critical regulator of cell response to MYC-targeting therapies.

Deciphering the impact of metabolic intervention on response to anticancer therapy may elucidate a path toward improved clinical responses. Here, we identify amino acid-related pathways connected to the folate cycle whose activation predicts sensitivity to MYC-targeting therapies in acute myeloid le...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Su, Angela, Ling, Frank, Vaganay, Camille, Sodaro, Gaetano, Benaksas, Chaïma, Bello, Reinaldo Dal, Forget, Antoine, Pardieu, Bryann, Lin, Kevin H., Rutter, Justine C., Bassil, Christopher F., Fortin, Gael, Pasanisi, Justine, Antony-Debré, Iléana, Alexe, Gabriela, Benoist, Jean-François, Pruvost, Alain, Pikman, Yana, Qi, Jun, Schlageter, Marie-Hélène, Micol, Jean-Baptiste, Roti, Giovanni, Cluzeau, Thomas, Dombret, Hervé, Preudhomme, Claude, Fenouille, Nina, Benajiba, Lina, Golan, Hava M., Stegmaier, Kimberly, Lobry, Camille, Wood, Kris C., Itzykson, Raphael, Puissant, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044910/
https://ncbi.nlm.nih.gov/pubmed/32826232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0970
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