The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Expression of the EVI1 proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloid leukemia (AML) and is associated with poor clinical outcome. Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 overexpression alters cell...

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Bibliographic Details
Published in:Nat Med
Main Authors: Fenouille, Nina, Bassil, Christopher F., Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S., Burgess, Michael R., Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J., Stone, Richard M., Zhang, Yi, Perkins, Archibald S., Shannon, Kevin, Hemann, Michael T., Puissant, Alexandre, Stegmaier, Kimberly
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540325/
https://ncbi.nlm.nih.gov/pubmed/28191887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4283
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