SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia

SUMMARY: Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify...

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Xehetasun bibliografikoak
Egile Nagusiak: Puissant, Alexandre, Fenouille, Nina, Alexe, Gabriela, Pikman, Yana, Bassil, Christopher F., Mehta, Swapnil, Du, Jinyan, Kazi, Julhash U., Luciano, Frédéric, Rönnstrand, Lars, Kung, Andrew L., Aster, Jon C., Galinsky, Ilene, Stone, Richard M., DeAngelo, Daniel J., Hemann, Michael T., Stegmaier, Kimberly
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106711/
https://ncbi.nlm.nih.gov/pubmed/24525236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.022
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