WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with high incidences of p53 mutations. AZD1775 (adavosertib, previously MK-1775) is a small molecule WEE1 inhibitor that abrogates the G2M checkpoint and can potentially synergize with DNA damaging therapies commonly used in PDAC trea...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Hartman, Sarah J., Bagby, Stacey M., Yacob, Betelehem W., Simmons, Dennis M., MacBeth, Morgan, Lieu, Christopher H., Davis, S. Lindsey, Leal, Alexis D., Tentler, John J., Diamond, Jennifer R., Eckhardt, S. Gail, Messersmith, Wells A., Pitts, Todd M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044903/
https://ncbi.nlm.nih.gov/pubmed/33869031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.642328
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge