WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with high incidences of p53 mutations. AZD1775 (adavosertib, previously MK-1775) is a small molecule WEE1 inhibitor that abrogates the G2M checkpoint and can potentially synergize with DNA damaging therapies commonly used in PDAC trea...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Hartman, Sarah J., Bagby, Stacey M., Yacob, Betelehem W., Simmons, Dennis M., MacBeth, Morgan, Lieu, Christopher H., Davis, S. Lindsey, Leal, Alexis D., Tentler, John J., Diamond, Jennifer R., Eckhardt, S. Gail, Messersmith, Wells A., Pitts, Todd M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044903/
https://ncbi.nlm.nih.gov/pubmed/33869031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.642328
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