Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype defined by lack of hormone receptor expression and non-amplified HER2. Adavosertib (AZD1775) is a potent, small-molecule, ATP-competitive inhibitor of the Wee1 kinase that potentiates the activity of many DNA-damaging chemotherapeutics an...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Pitts, Todd M., Simmons, Dennis M., Bagby, Stacey M., Hartman, Sarah J., Yacob, Betelehem W., Gittleman, Brian, Tentler, John J., Cittelly, Diana, Ormond, D. Ryan, Messersmith, Wells A., Eckhardt, S. Gail, Diamond, Jennifer R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140086/
https://ncbi.nlm.nih.gov/pubmed/32204315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030719
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