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Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells
Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal epithelium. We report that aged intestinal crypts present with...
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| Yayımlandı: | iScience |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044426/ https://ncbi.nlm.nih.gov/pubmed/33870147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102362 |
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