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Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells
Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal epithelium. We report that aged intestinal crypts present with...
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| Vydáno v: | iScience |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044426/ https://ncbi.nlm.nih.gov/pubmed/33870147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102362 |
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